Laboratory
and animal confirmation as well as epidemiological data suggest that vitamin D
status could involve cancer risk. Strong biological and mechanistic bases point
out that vitamin D plays a role in the deterrence of colon, prostate, and
breast cancers. Emerging epidemiological data advice that vitamin D may have a
defensive effect against colon cancer, but the data are not as strong for a
caring effect alongside prostate and breast cancer, and are erratic for cancers
at other sites .Studies do not time after time show a caring or no effect,
however. One study of Finnish smokers, for example, originate that subjects in
the highest quin tile of baseline vitamin D status had a threefold higher risk
of developing pancreatic cancer .A current review found an increased risk of
pancreatic cancer associated with high levels of serum.Vitamin D emerged as a
protective factor in a forthcoming, cross-sectional study of 3,121 adults aged
≥50 years (96% men) who underwent a colonoscopy. The study found that 10% had
at least one advanced cancerous lesion. Those with the highest vitamin D
intakes (>645 IU/day) had a drastically lower risk of these lesions
.However, the Women's Health scheme, in which 36,282 postmenopausal women of
various races and ethnicity were randomly assigned to receive 400 IU vitamin D
plus 1,000 mg calcium daily or a placebo, found no significant differences
between the groups in the frequency of correctional cancers over 7 years .More
newly, a clinical trial focused on bone health in 1,179 postmenopausal women
residing in rural Nebraska found that subjects supplemented each day with
calcium and vitamin D3 (1,100 IU) had a significantly lower
incidence of cancer over 4 years compared with women taking a placebo .The
small number of cancers (50) precludes generalizing about a protective outcome
from either or both nutrients or for cancers at unlike sites. This watchfulness
is supported by an analysis of 16,618 participants in NHANES III (1988–1994),
in which total cancer mortality was found to be unrelated to baseline vitamin D
status .However, collector cancer mortality was inversely associated to serum
25(OH)D concentrations. A large observational study with participants from 10
western European countries also found a strong contradictory association
between prognosticate 25(OH)D concentrations and danger of correctional cancer
.
